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1.
Int. j. odontostomatol. (Print) ; 17(2): 130-135, jun. 2023. tab
Article in Spanish | LILACS | ID: biblio-1440350

ABSTRACT

El cuerpo adiposo de la boca (CAB) es un componente adiposo multilobulado bien delimitado, localizado de manera bilateral en la región facial íntimamente relacionado a estructuras nerviosas y vasculares. La remoción de CAB es un procedimiento ampliamente estudiado en el campo de la cirugía maxilofacial, utilizado principalmente para cubrir defectos. Su influencia en la estética facial ha iniciado una popularización de la remoción de la extensión bucal de CAB para obtener un rostro más estilizado, intervención difundida como poco invasiva y sin complicaciones. El objetivo de este estudio fue recopilar y evaluar estudios que reporten y evalúen complicaciones asociadas a la remoción por razones estéticas de CAB. Se revisó la evidencia en las bases de datos Medline vía PubMed, Epistemonikos, Scopus y Google Scholar, utilizando términos predefinidos, seleccionando estudios primarios de reportes de casos. Se incluyeron 7 artículos con un total de 10 pacientes; de estos, ocho pacientes se realizaron este procedimiento en Brasil, uno en Estados Unidos y uno en Chile. La distribución de la población fue de 3:7 entre hombres y mujeres con edad promedio de 35 años y un rango entre los 23 a los 49 años. En relación a las complicaciones reportadas, 100 % de los pacientes presentaron asimetría facial, un 80 % presentó edema facial, 30 % manifestaron sialocele, Trismus 20 %, 40 % presentó hematoma, 20 % compromiso del estado general, 20 % presentaron disfagia, en los casos de hipoestesia, parestesia, absceso, seroma, parálisis facial, odinofagia, fiebre se expresaron en 10 % de la población estudiada. En todos los estudios se describió una reintervención quirúrgica posterior a la remoción estética del cuerpo adiposo de bichat. La escasa literatura y la baja calidad de esta, no permite estimar el porcentaje real de posibles complicaciones, tampoco es posible determinar sus resultados a largo plazo ya que no existe en la evidencia un seguimiento apropiado para estos pacientes.


The buccal adipose body (BAB) is a well- defined multilobulated adipose component, located bilaterally in the facial region, closely related to nervous and vascular structures. BAB removal is a widely studied procedure in the field of maxillofacial surgery, used mainly to cover defects. Its influence on facial aesthetics has started to popularize the removal of the BAB buccal extension to obtain a more stylized face, an intervention widely known as minimally invasive and without complications. The objective of this study was to collect and evaluate studies that report and evaluate complications associated with the removal of BAB for cosmetic reasons. The evidence was reviewed in the Medline databases via PubMed, Epistemonikos, Scopus, and Google Scholar, using predefined terms, selecting primary studies from case reports. 7 articles with a total of 10 patients were included; Of these, eight patients underwent this procedure in Brazil, one in the United States, and one in Chile. The distribution of the population was 3:7 between men and women with an average age of 35 years and a range between 23 to 49 years. In relation to the reported complications, 100 % of the patients presented facial asymmetry, 80 % presented facial edema, 30 % manifested sialocele, trismus 20 %, 40 % presented hematoma, 20 % compromised general state, 20 % presented dysphagia, in the cases of hypoesthesia, paresthesia, abscess, seroma, facial paralysis, odynophagia, fever were expressed in 10 % of the studied population. All the studies described a surgical reintervention after cosmetic removal of the bichat adipose body. The scarce literature and its low quality do not allow estimating the real percentage of possible complications, nor is it possible to determine their long-term results since there is no evidence of appropriate follow-up for these patients.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Adipose Tissue/surgery , Oral Surgical Procedures/adverse effects , Cheek/surgery , Plastic Surgery Procedures/adverse effects
2.
Rev. Asoc. Odontol. Argent ; 110(1): 26-30, abr. 2022. ilus
Article in Spanish | LILACS | ID: biblio-1382209

ABSTRACT

Objetivo: Presentar la resolución quirúrgica de un caso clínico poco frecuente en un paciente pediátrico luego de ha- ber sufrido la herniación traumática de la Bola Adiposa de Bichat. Caso clínico: Un paciente de 3 años concurre a la guar- dia del Hospital Interzonal Especializado Materno Infantil "Don Victorio Tetamanti" de Mar del Plata, luego de haber sufrido un traumatismo que le provocó el desplazamiento par- cial de la Bola Adiposa de Bichat. Si bien este tipo de urgencias es poco frecuente, es impor- tante tener los conocimientos para un correcto diagnóstico y tratamiento (AU))


Aim: To present the surgical resolution of an infrequent clinical case in a pediatric patient who suffered traumatic herniation of Bichat's fat pad. Clinical case: A 3-year-old patient who visited the Emergency Service at the "Don Victorio Tetamanti" Hospital in Mar del Plata after suffering a trauma which caused the partial displacement of Bichat's fat pad. Although this type of emergency is quite rare, it is important to know how to per- form proper diagnosis and treatment (AU)


Subject(s)
Humans , Female , Child, Preschool , Adipose Tissue/surgery , Dental Service, Hospital , Emergencies , Hospitals, Pediatric , Argentina , Biopsy/methods , Adipose Tissue/diagnostic imaging , Oral Surgical Procedures/methods , Mouth Mucosa/injuries
3.
Int. j. morphol ; 39(1): 123-133, feb. 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1385296

ABSTRACT

RESUMEN: El presente estudio busca entregar conocimientos y aspectos importantes de las estructuras anatómicas asociadas al cuerpo adiposo de la mejilla (CAM), a consecuencia del reporte de un caso de complicación posterior a una bichectomía. Conocer los elementos anatómicos y sus relaciones con el CAM es de vital importancia, ya que en la actualidad son muchos los cursos y pasadas que se realizan para odontólogos generales y especialistas para el retiro del CAM, esto producto de la creciente demanda estética de las personas por presentar un perfil más fino y estilizado. El caso presentado corresponde a una mujer que consultó al servicio de urgencia por aumento de volumen facial posterior a la extracción del CAM, el cual se diagnosticó como sialocele, consecutivo a daño del conduc- to parotídeo. Al revisar la literatura y observar en nuestros preparados anatómicos se aprecia la cercanía de elementos de importancia, como son el conducto parotídeo, los ramos cigomático y bucal del nervio facial, vasos faciales como la arteria facial, vena facial y arteria transversa facial, es por esto que es necesario conocer en detalle la zona a intervenir y considerar las posibles variaciones anatómicas de estos elementos, para así evitar dañarlos durante el procedimiento, tomando una actitud preventiva. Apuntado entonces al objetivo de este estudio, fue lograr entregar información anatómica precisa y concisa de los elementos de importancia próximos o inmersos en el CAM, para prevenir la iatrogenia de estos.


SUMMARY: The present study seeks to provide knowledge and important aspects of the anatomical structures associated with the buccal fat pad (BFP), as consequence of the report of a case of complication after bichectomy. Knowing the anatomical elements and their relationships with BFP is of vital importance, because nowadays there are too many BFP removal courses and internships, for general dentists and specialists, due to the increasing aesthetic demands of individuals seeking a finer and more stylized profile. The case presented is a female patient who consults the emergency department for an increase in facial volume after BFP extraction, which was diagnosed as sialocele, following damage to the parotid duct. When reviewing the literature and observing our anatomical preparations, the proximity of important elements is appreciated, such as the parotid duct, the zygomatic and buccal branches of the facial nerve, facial vessels such as the facial artery, facial vein and facial transverse artery. It is essential to know in detail the area in order to intervene and consider the possible anatomical variations of these elements to avoid injury during the procedure. The aimed objective of this study, is to provide accurate and concise anatomical information of important elements near or immersed in BFP, to prevent iatrogenesis.


Subject(s)
Humans , Female , Adult , Cheek/anatomy & histology , Cheek/surgery , Adipose Tissue/anatomy & histology , Adipose Tissue/surgery , Plastic Surgery Procedures , Lipectomy , Cheek/diagnostic imaging , Adipose Tissue/diagnostic imaging
4.
Rev. bras. cir. plást ; 34(4): 458-467, oct.-dec. 2019. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-1047901

ABSTRACT

Introdução: A lipoaspiração tem sido submetida à evolução constante desde a sua consolidação e emprego sistemático. O auxílio de tecnologia ultrassônica de terceira geração, VASER® (Vibration Amplification of Sound Energy at Resonance), se destina a facilitar a execução da lipoaspiração e trazer maior segurança e resultados satisfatórios, especialmente na busca por maior definição e lipoaspiração superficial. Métodos: No período de 2015 a 2017, 76 pacientes foram submetidas à lipoaspiração para melhora de contorno corporal no Centro Hospitalar Santa Mônica em Erechim. Foram avaliados os resultados obtidos, as possíveis complicações e a segurança do emprego do VASER®. Resultados: A utilização rotineira do VASER® gera aperfeiçoamento de resultados em contorno corporal. A emulsificação gerada pelo dispositivo associada à lipoaspiração em diversos níveis permite uma maior definição e evidenciação dos marcos anatômicos. Conclusão: Lipoaspiração associada ao VASER® permite ao cirurgião plástico o refinamento de seus resultados com a preservação da segurança do paciente.


Introduction: Liposuction has been improved continuously since it was first introduced. The third-generation ultrasound technology VASERTM (Vibration Amplification of Sound Energy at Resonance) facilitates liposuction, providing improved safety and satisfactory results, especially in the search for greater definition and superficial liposuction. Methods: From 2015 to 2017, 76 patients underwent liposuction to improve their body contour at the Santa Monica Hospital Center in Erechim, Rio Grande do Sul, Brazil. The results, complications, and the safety of VASERTM were evaluated. Results: The routine use of VASERTM improves body contour. The emulsification generated by the device, along with liposuction, resulted in greater definition and revelation of the anatomical landmarks. Conclusion: Liposuction associated with VASERTM allows plastic surgeons to refine the results better while ensuring patient safety is maintained.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , History, 21st Century , Postoperative Complications/surgery , Surgical Procedures, Operative , Lipectomy , Adipose Tissue , Subcutaneous Fat/surgery , Patient Safety/standards , Body Contouring , Lipodystrophy , Postoperative Complications , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methods , Lipectomy/methods , Adipose Tissue/surgery , Subcutaneous Fat , Patient Safety , Body Contouring/adverse effects , Body Contouring/methods , Lipodystrophy/surgery , Lipodystrophy/complications
5.
Int. j. odontostomatol. (Print) ; 12(4): 362-367, dic. 2018. tab
Article in Spanish | LILACS | ID: biblio-975758

ABSTRACT

RESUMEN: Uno de los objetivos de la cirugía maxilofacial es devolver anatomía, función y estética a través de distintas técnicas quirúrgicas. Dentro de los tejidos utilizados para esto se encuentra el cuerpo adiposo de la mejilla (CAM). La gran evidencia clínica existente y el conocimiento que se tiene acerca de este tejido ha permitido poder utilizarlo como injerto o colgajo para el tratamiento de una serie de condiciones que afectan al territorio maxilofacial con buenos resultados tanto estéticos como funcionales. Describir las diferentes indicaciones que tiene el CAM como colgajo e injerto autólogo para el tratamiento de las distintas anomalías que afectan al territorio maxilofacial. Se realizó una búsqueda entre abril y junio de 2018 utilizando 3 bases de datos electrónicas: PubMed, EBSCO y Cochrane. Las palabras clave utilizadas fueron buccal fat pad, bichat's fat pad y oral surgery con la selección del término booleano AND y OR. Se seleccionaron aquellos estudios publicados entre los 2014 y 2018, de texto completo. Se seleccionaron 17 artículos de que cumplieron con los criterios de inclusión; 2 revisiones sistemáticas, 8 ensayos clínicos, 6 estudios observacionales y una serie de casos. El uso del CAM como injerto y colgajo para la corrección de anomalías en el territorio maxilofacial es una técnica versátil y predecible. La totalidad de los estudios analizados avalan su uso en dicho campo. Se necesitan más estudios clínicos aleatorizados, con un mayor número de casos, seguimiento a largo plazo y parámetros a evaluar para establecer una conclusión final sobre el uso del CAM en las diversas aplicaciones de la cirugía maxilofacial.


ABSTRACT: One of the main objectives of maxillofacial surgery is to restore patient normal anatomy, function and esthetic. Among the various tissues used to achieve the above, is the buccal fat pad. Currently, there is sufficient clinical evidence and knowledge regarding this tissue type, to approve its use as graft or flap, in order to treat a number of conditions that affect the maxillofacial area. Furthermore, it has shown various esthetical as well as functional results. The purpose of this narrative review is to describe different indications of the buccal fat pad, as a flap and autologous graft in treating various maxillofacial abnormalities. A search was conducted between april and june 2018 using 3 electronic data bases: PubMed, EBSCO and Cochrane library. Key words used were buccal fat pad, Bichat's fat pad y oral surgery using Boolean terms AND/ OR. Studies published between 2014 and 2018 were selected. For the study, 17 complete text studies that met the inclusion criteria were selected; two systematic reviews, eight randomized clinical trials, six observational studies and one case series. The use of the buccal fat pad as flap and graft for correcting maxillofacial abnormalities, is a predictable and versatile technique. The total number of studies analyzed, support its use in this surgical field. In conclusion and despite these results however, there is a need for further randomized clinical trials with a greater number of cases, long term follow up, and greater parameter assessment to support the use of the buccal fat pad in maxillofacial surgery.


Subject(s)
Humans , Surgery, Oral/methods , Oral Surgical Procedures/methods , Maxillary Osteotomy/methods , Adipose Tissue/anatomy & histology , Adipose Tissue/surgery
6.
Rev. bras. cir. plást ; 33(4): 446-452, out.-dez. 2018. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-979940

ABSTRACT

Introdução: O tecido gorduroso bucal foi descrito pela primeira vez em 1732, por Heister. Em 1802, Bichat diagnosticou sua natureza adiposa. Há uma estreita relação entre a gordura bucal e músculos da mastigação, auxiliando os lactentes na sucção do leite por atuar com um tecido de deslizamento. Sua projeção diminui com o aumento da idade, tanto pela redução discreta de seu volume quanto pelo crescimento facial. A bichectomia ou bichatectomia é o procedimento cirúrgico que visa remover a "bola gordurosa de Bichat", com fins estéticos e/ ou funcionais. O objetivo é demonstrar que a bichectomia é um procedimento de baixo risco cirúrgico e com bons resultados, desde que seja bem indicada e siga os padrões técnicos, respeitando a anatomia das estruturas faciais. Métodos: Estudo prospectivo de coorte, realizado entre janeiro de 2016 e abril de 2018, totalizando 59 pacientes, com média de idade de 31 anos. O tempo de seguimento foi de 12 a 26 meses. Resultados: Foram avaliados 59 pacientes, com média de idade de 31 anos, sendo 46 do sexo feminino e 13 do sexo masculino. Todos os pacientes receberam alta no mesmo dia. Em média, foram retirados 3,2ml de volume da gordura de Bichat. Conclusão: A retirada de porções das gorduras de Bichat é segura, desde que sejam observados os detalhes anatômicos. Pode oferecer maior harmonia entre os três terços da face. O sucesso dos resultados depende de uma indicação precisa para o procedimento.


Introduction: Buccal fat removal was described for the first time by Heister in 1732. In 1802, Bichat identified the adipose nature of this tissue. There is a close association between buccal fat and masticatory muscles, which helps infants suck owing to the sliding motion of the tissues. Its prominence diminishes with age, both through modest reduction in volume and facial growth. Bichectomy or bichatectomy is a surgical procedure that involves extraction of Bichat's fat pad for aesthetic and/or functional purposes. This study aimed to show that bichectomy is a low-risk surgical procedure with good results, provided it is appropriately indicated and is performed following technical standards according to the anatomy of the facial structures. Methods: This prospective cohort study was conducted between January 2016 and April 2018 and included 59 patients with a mean age of 31 years. The follow-up time was 12-26 months. Results: Of 59 patients, 46 were female, and 13 were male. All patients underwent same-day surgery. On average, 3.2 mL of fat was removed. Conclusion: Removal of Bichat's fat according to anatomical principles is safe. This technique can improve facial harmony. Success depends on application of appropriate techniques.


Subject(s)
Humans , Male , Female , Adult , Adipose Tissue/anatomy & histology , Adipose Tissue/surgery , Oral Surgical Procedures/methods , Plastic Surgery Procedures/methods , Facial Asymmetry/surgery , Mouth/anatomy & histology , Mouth/surgery , Fats
7.
Rev. bras. anestesiol ; 66(3): 324-328, May.-June 2016. tab, graf
Article in English | LILACS | ID: lil-782894

ABSTRACT

ABSTRACT BACKGROUND AND OBJECTIVES: Fat embolism syndrome may occur in patients suffering from multiple trauma (long bone fractures) or plastic surgery (liposuction), compromising the circulatory, respiratory and/or central nervous systems. This report shows the evolution of severe fat embolism syndrome after liposuction and fat grafting. CASE REPORT: SSS, 42 years old, ASA 1, no risk factors for thrombosis, candidate for abdominal liposuction and breast implant prosthesis. Subjected to balanced general anesthesia with basic monitoring and controlled ventilation. After 45 min of procedure, there was a sudden and gradual decrease of capnometry, severe hypoxemia and hypotension. The patient was immediately monitored for MAP and central catheter, treated with vasopressors, inotropes, and crystalloid infusion, stabilizing her condition. Arterial blood sample showed pH = 7.21; PCO2 = 51 mmHg; PO2 = 52 mmHg; BE = -8; HCO3 = 18 mEq L-1, and lactate = 6.0 mmol L-1. Transthoracic echocardiogram showed PASP = 55 mmHg, hypocontractile VD and LVEF = 60%. Diagnosis of pulmonary embolism. After 24 h of intensive treatment, the patient developed anisocoria and coma (Glasgow coma scale = 3). A brain CT was performed which showed severe cerebral hemispheric ischemia with signs of fat emboli in right middle cerebral artery; transesophageal echocardiography showed a patent foramen ovale. Finally, after 72 h of evolution, the patient progressed to brain death. CONCLUSION: Fat embolism syndrome usually occurs in young people. Treatment is based mainly on the infusion of fluids and vasoactive drugs, mechanical ventilation, and triggering factor correction (early fixation of fractures or suspension of liposuction). The multiorgânico involvement indicates a worse prognosis.


RESUMO JUSTIFICATIVA E OBJETIVOS: A Síndrome da Embolia Gordurosa (SEG) pode acontecer em pacientes vítimas de politrauma (fratura de ossos longos) ou operações plásticas (lipoaspiração), comprometendo circulação, respiração e/ou sistema nervoso central. O presente relato mostra evolução de SEG grave após lipoaspiração e lipoenxertia. RELATO DO CASO: SSS, 42 anos, ASA 1, sem fatores de risco para trombose, candidata a lipoaspiração abdominal e implante de prótese mamária. Submetida à anestesia geral balanceada com monitorização básica e ventilação controlada. Após 45 minutos de procedimento, houve queda súbita e progressiva da capnometria, hipoxemia e hipotensão grave. Imediatamente foi monitorizada com PAM e cateter central, tratada com vasopressores, inotrópicos e infusão de cristaloides, obtendo estabilização do quadro. Amostra sanguínea arterial mostrou pH = 7,21; PCO2 = 51 mmHg; PO2 = 52 mmHg; BE = -8; HCO3 = 18 mEQ/l e lactato = 6,0 mmol/l. Ecocardiograma transtorácico mostrou PSAP = 55 mmHg, VD hipocontrátil e FEVE = 60%. Diagnóstico de embolia pulmonar. Após24 h de tratamento intensivo, a paciente evoluiu com anisocoria e coma com escala de glasgow 3. Realizada TC de encéfalo que evidenciou isquemia cerebral grave, hemisférica, com sinais de êmbolos de gordura em A. cerebral média D; o ecocardiograma transesofágico mostrou forame oval patente. Finalmente, após 72 h de evolução, a paciente evoluiu para morte encefálica. CONCLUSÃO: A SEG ocorre geralmente em jovens. O tratamento baseia-se principalmente na infusão de líquidos e drogas vasoativas, ventilação mecânica e correção do fator desencadeante (fixação precoce de fraturas ou suspensão da lipoaspiração). O comprometimento multiorgânico indica pior prognóstico.


Subject(s)
Humans , Female , Adult , Lipectomy/adverse effects , Brain Ischemia/complications , Adipose Tissue/surgery , Embolism, Fat/complications , Abdomen/surgery , Respiration, Artificial , Syndrome , Severity of Illness Index , Brain Death/physiopathology , Brain Death/diagnostic imaging , Tomography, X-Ray Computed , Brain Ischemia/physiopathology , Brain Ischemia/diagnostic imaging , Fatal Outcome , Echocardiography, Transesophageal , Middle Cerebral Artery/physiopathology , Middle Cerebral Artery/diagnostic imaging , Embolism, Fat/diagnostic imaging , Foramen Ovale, Patent/complications , Foramen Ovale, Patent/physiopathology , Foramen Ovale, Patent/diagnostic imaging , Perioperative Period , Intraoperative Complications/physiopathology , Intraoperative Complications/diagnostic imaging , Anesthesia, General
8.
Rev. bras. cir. plást ; 31(1): 112-117, jan.-mar. 2016. ilus
Article in English, Portuguese | LILACS | ID: biblio-1545

ABSTRACT

INTRODUÇÃO: Lipomas são os tumores benignos mesenquimais mais comuns. Entretanto, são pouco frequentes na face, principalmente o tipo considerado gigante, derivado do coxim adiposo bucal. A literatura é escassa e provavelmente a sua incidência é subestimada. MÉTODO: Relato do caso de tratamento cirúrgico de lipoma gigante bucal e temporal recidivado, e revisão da literatura no Pubmed na língua inglesa e na Revista Brasileira de Cirurgia Plástica. RESULTADOS: O tumor, anatômica e morfologicamente, corresponde ao coxim adiposo bucal, foi totalmente retirado pelo acesso facial e temporal, sem sequelas ao nervo facial. Foram encontrados 31 casos relatados de lipoma de origem do coxim adiposo bucal, entretanto, vários casos foram encontrados e relatados sob outras denominações. DISCUSSÃO: O coxim adiposo bucal é maior e mais complexo que se conhecia, e várias patologias se derivam deste, sendo importante o diagnóstico diferencial do lipoma simples com o de células fusiformes e com o lipossarcoma, devido a sua extrema semelhança. CONCLUSÃO:Nas lesões lipomatosas da face, a possível origem no coxim adiposo bucal deve ser considerada. Um estudo amplo dessas lesões com a finalidade de uniformizar a terminologia e de determinar a sua real incidência deve ser realizado.


INTRODUCTION: Lipomas are the most common benign mesenchymal tumors. Nevertheless, they are infrequent in the face, particularly giant lipomas, which are derived from the buccal fat pad. The literature regarding these tumors is scarce and their incidence is likely underestimated. METHODS: We present a case report of surgical treatment of a relapsed giant buccal and temporal lipoma and review the related English literature in Pubmed and that in the Brazilian Journal of Plastic Surgery. RESULTS: The tumor, which anatomically and morphologically corresponded to the buccal fat pad, was completely excised by facial and temporal access without sequelae to the facial nerve. A total of 31 reported cases of lipoma originating from the buccal fat pad were found; however, several were found and reported under other names. DISCUSSION: The buccal fat pad is larger and more complex than assumed, and several pathologies are derived thereof, making the differential diagnosis of simple lipoma with fusiform cell lipoma and liposarcoma difficult due to their extreme similarities. CONCLUSION: In lipomatous lesions of the face, the possible origin in the buccal fat pad must be considered. An extensive study of these lesions with the purpose of standardizing the terminology and determining its real incidence must be performed.


Subject(s)
Humans , Male , Adult , History, 21st Century , Wounds and Injuries , Lipomatosis, Multiple Symmetrical , Case Reports , Adipose Tissue , Review , Oral Surgical Procedures , Face , Lipoma , Lipomatosis , Mouth , Neoplasm Recurrence, Local , Neoplasms , Wounds and Injuries/surgery , Wounds and Injuries/complications , Lipomatosis, Multiple Symmetrical/surgery , Lipomatosis, Multiple Symmetrical/pathology , Adipose Tissue/surgery , Adipose Tissue/growth & development , Oral Surgical Procedures/methods , Face/surgery , Face/pathology , Lipoma/surgery , Lipoma/pathology , Lipomatosis/surgery , Lipomatosis/pathology , Mouth/anatomy & histology , Mouth/surgery , Mouth/growth & development , Mouth/physiopathology , Neoplasm Recurrence, Local/surgery , Neoplasm Recurrence, Local/pathology , Neoplasms/surgery
9.
Rev. bras. cir. plást ; 31(3): 417-423, 2016. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-2314

ABSTRACT

No Brasil, 1 milhão de acidentes com queimaduras acontecem por ano e as infecções são responsáveis por 75% dos óbitos nestes pacientes, além de deixar lesões que ocasionam deformidades nas áreas atingidas. Sendo assim, o objetivo deste trabalho é fornecer uma visão atual sobre células-tronco mesenquimais (MSCs), com ênfase nas células-tronco derivadas do tecido adiposo (ADSCs), associadas a gel de plasma, gel de fibrina e membranas (scaffold). O uso de géis e membranas tendem a auxiliar o crescimento celular visando sua possível aplicação na Cirurgia Plástica Reparadora para o tratamento pacientes queimados ou que necessitam de enxerto de pele. O presente trabalho abordou de forma exploratória e narrativa o tema células-tronco mesenquimais, células-tronco mesenquimais derivadas do tecido adiposo, gel de fibrina, gel de plasma e scaffold. O tipo de pesquisa empregada foi conduzido com coleta de informações utilizando-se a Biblioteca Virtual em Saúde (BVS) e PubMed. O número absoluto de artigos publicados relacionados ao tratamento de queimaduras é considerável. Até o momento, a quantidade de pesquisas relacionadas à terapia com células-tronco derivadas do tecido adiposo, gel de fibrina, gel de plasma e scaffold para o tratamento de queimaduras apresenta-se escassa. O autoenxerto de ADSCs associado a biocurativos torna-se uma perspectiva promissora na Cirurgia Plástica Reparadora para o tratamento e recuperação de pacientes que sofreram queimaduras ou outros acidentes que necessitam de enxerto de pele. Estes recursos podem reduzir a dor e prover a dessecação da lesão, promovendo neovascularização e a reepitelização da ferida.


In Brazil, 1 million burn accidents occur annually, and subsequent wound infections account for 75% cases of deaths among these patients, in addition to inducing deformities in the affected areas. Therefore, the aim of this study was to discuss the current status of mesenchymal stem cells, with an emphasis on adipose-derived stem cells (ADSCs), in combination with plasma gel, glue fibrin, and membranes (scaffold). The use of gels and membranes supports cell growth, and aims at potential application in reconstructive plastic surgery for the treatment of burn patients or individuals requiring skin grafts. This study explores and discusses the role of mesenchymal stem cells, adipose-derived mesenchymal stem cells, glue fibrin, plasma gel, and the scaffold. This research collected information from the Virtual Health Library (VHL) and PubMed. A considerable number of articles have been published on burn treatment. However, there is little research on burn treatment with ADSCs, glue fibrin, plasma gel, and scaffold. An ADSC autograft combined with a biological dressing is promising in reconstructive plastic surgery for the treatment and recovery of burn patients or individuals with other injuries that require skin grafts. These features can reduce pain and aid in drying of the lesion, thus promoting neovascularization and wound reepithelialization.


Subject(s)
Humans , History, 21st Century , Skin , Transplantation, Autologous , Bioprosthesis , Burns , Cell Membrane , Review , Plastic Surgery Procedures , Mesenchymal Stem Cells , Gels , Skin/injuries , Transplantation, Autologous/methods , Bioprosthesis/adverse effects , Bioprosthesis/standards , Burns/surgery , Burns/complications , Cell Membrane/pathology , Cell Membrane/transplantation , Adipose Tissue , Adipose Tissue/surgery , Adipose Tissue/injuries , Plastic Surgery Procedures/methods , Mesenchymal Stem Cells/pathology , Gels/adverse effects , Gels/therapeutic use , Neovascularization, Pathologic , Neovascularization, Pathologic/surgery , Neovascularization, Pathologic/pathology , Neovascularization, Pathologic/therapy
10.
Rev. bras. cir. plást ; 30(1): 33-37, 2015. ilus, tab
Article in English, Portuguese | LILACS | ID: biblio-866

ABSTRACT

INTRODUÇÃO: Os lipomas são os tumores mesenquimais benignos mais frequentes na população. Para ser considerado gigante, deve apresentar pelo menos 10 cm em uma de suas dimensões ou pesar ao menos 1.000g. O objetivo do trabalho é analisar uma série de casos de lipomas gigantes atendidos em nosso serviço. MÉTODO: Análise retrospectiva de prontuários e registros anatomopatológicos dos diagnósticos de lipomas submetidos a tratamento cirúrgico no período de janeiro 2003 a janeiro 2010. RESULTADOS: Foram avaliados 14 pacientes, com média de idade de 52,3 anos (33-72) e tempo médio de evolução até o tratamento de 4,4 anos (seis meses - 20 anos); 64% dos casos não apresentavam sintomas. Todos os pacientes foram submetidos à ressecção cirúrgica da neoplasia. O peso médio das peças foi de 3,8 kg (512 g - 22 kg) e o tamanho médio no maior eixo foi de 27,5 cm (15-66 cm). Foram observadas complicações pós-operatórias em 42% dos casos. CONCLUSÃO: Observamos períodos prolongados de evolução até o tratamento, mesmo em casos com lesões de grande volume. A exérese cirúrgica aberta deve ser considerada o tratamento de eleição para estes tumores.


INTRODUCTION: Lipomas are the most common benign mesenchymal tumors worldwide. To be considered giant, they must be at least 10 cm in one of its dimensions or weigh at least 1,000 g. The objective of this study is to analyze a series of cases of giant lipomas seen in our practice. METHOD: We conducted a retrospective analysis of the medical and anatomopathological records of patients diagnosed with lipomas who underwent surgery between January 2003 and January 2010. RESULTS: We evaluated 14 patients with a mean age of 52.3 years (range, 33-72 years) and a mean evolution time until treatment of 4.4 years (range, 6 months to 20 years); 64% of cases presented no symptoms. All patients underwent surgical tumor resection. The average weight of the pieces was 3.8 kg (range, 512 g to 22 kg), while the average length of the longest axis was 27.5 cm (range, 15-66 cm). Postoperative complications were observed in 42% of cases. CONCLUSION: We observed prolonged periods of evolution until treatment, even in cases of large-volume lesions. Open surgical excision should be considered the treatment of choice for these tumors.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , History, 21st Century , Postoperative Complications , Case Reports , Review Literature as Topic , Adipose Tissue , Medical Records , Retrospective Studies , Adipocytes , Evaluation Study , Lipoma , Lipomatosis , Neoplasms , Postoperative Complications/surgery , Postoperative Complications/therapy , Adipose Tissue/surgery , Adipose Tissue/physiopathology , Medical Records/standards , Adipocytes/physiology , Adipocytes/pathology , Lipoma/surgery , Lipoma/pathology , Lipomatosis/surgery , Lipomatosis/pathology , Neoplasms/surgery , Neoplasms/pathology
11.
Rev. bras. cir. plást ; 30(3): 423-428, 2015. ilus
Article in English, Portuguese | LILACS | ID: biblio-1151

ABSTRACT

INTRODUÇÃO: As sequelas de mastectomia se apresentam de formas variadas exigindo, do cirurgião, experiência e criatividade para obter o melhor resultado na reconstrução de uma nova mama. Dentre as dificuldades para que este objetivo seja alcançado, está o desafio de um melhor preenchimento do polo superior da mama. O objetivo deste trabalho é apresentar uma opção terapêutica alternativa para correção do polo superior dentre as técnicas já existentes com este propósito. MÉTODO: A técnica cirúrgica utilizou o retalho de músculo grande dorsal com extensão gordurosa para preenchimento do polo superior da neomama durante sua reconstrução. A técnica descrita foi utilizada em 8 pacientes durante a reconstrução mamária tardia, com idades variando entre 39 e 70 anos. O tamanho desta extensão gordurosa variou entre 4,0 × 10,0 e 7,0 × 13,0 cm. O componente gorduroso do retalho foi avaliado após 3 meses através de ressonância magnética. RESULTADOS: Foram usados implantes mamários que variavam entre 270 e 435 ml. O acompanhamento pós operatório variou entre 3 meses a 1 ano. Ocorreram 2 casos de epidermólise (28%) na junção do retalho cutâneo com a área receptora. Não houve perda ou sofrimento do retalho. Os resultados demonstram clinicamente ou visualmente que a correção da depressão do polo superior da neomama foi alcançada adequadamente, bem como a viabilidade do retalho gorduroso, observada nos exames de imagem (ressonância magnética). CONCLUSÃO: A técnica proposta é uma alternativa adequada para o tratamento da maioria dos casos de reconstrução mamária em que se busca o preenchimento da depressão existente no polo superior da mama.


INTRODUCTION: The sequelae of mastectomy presents in numerous ways, requiring the experience and creativity of the surgeon to achieve the best result in the reconstruction of a new breast. One of the difficulties in achieving this objective is the challenge of adequately filling the upper pole of the breast. The objective of this work was to present an alternative therapeutic option for correction of the upper pole of the neobreast. METHODS: In our surgical technique, a latissimus dorsi muscle flap with fat extension is used for filling the upper pole of the neobreast during its reconstruction. The described technique was used in 8 patients during late breast reconstruction. The patients' ages ranged from 39 and 70 years. The size of the fat extension ranged from 4.0 × 10.0 cm to 7.0 × 13.0 cm. The fat component of the flap was evaluated after 3 months by using magnetic resonance imaging (MRI). RESULTS: Breast implants that varied in volume between 270 and 435 mL were used. The follow-up period after surgery ranged from 3 months to 1 year. Two patients had epidermolysis (28%) at the junction of the cutaneous flap and the receiver area. No graft loss or other complications occurred. Our results demonstrate clinically or visually that correction of the depression in the upper pole of the neobreast was satisfactorily achieved. The viability of the fat flap, as observed on MRI, was adequate. CONCLUSION: The proposed technique is a suitable alternative method for filling the depression in the upper pole of the neobreast in most cases of breast reconstruction.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , History, 21st Century , Radiotherapy , Breast , Adipose Tissue , Mammaplasty , Breast Implants , Plastic Surgery Procedures , Silicone Gels , Mammary Glands, Human , Fats , Superficial Back Muscles , Myocutaneous Flap , Radiotherapy/adverse effects , Radiotherapy/methods , Breast/surgery , Adipose Tissue/surgery , Mammaplasty/adverse effects , Mammaplasty/methods , Breast Implants/adverse effects , Plastic Surgery Procedures/methods , Silicone Gels/therapeutic use , Silicone Gels/pharmacology , Evaluation Study , Mammary Glands, Human/surgery , Fats/therapeutic use , Superficial Back Muscles/surgery , Myocutaneous Flap/surgery , Myocutaneous Flap/adverse effects
12.
Rev. chil. endocrinol. diabetes ; 7(2): 60-63, abr.2014. tab, ilus
Article in Spanish | LILACS | ID: lil-779320

ABSTRACT

Surgical procedures intended for treating obesity and related disorders, known as bariatric surgery or obesity surgery, have been performed for more than 60 years. Although there are several types of interventions, all of them produce sustained weight loss and some improvement in metabolic comorbidities such as type 2 diabetes, dyslipidemia and hypertension. The main mechanisms involved in postsurgical metabolic changes are weight loss mediated-decreased lipotoxicity, decreased caloric intake, and the incretin effect. Current indications for bariatric surgery are being reviewed due to its weight loss independent-benefits and, on the other hand, the limitations of conventional therapies...


Subject(s)
Humans , Bariatric Surgery , Obesity/surgery , Adipose Tissue/surgery , Risk Assessment
13.
Korean Journal of Ophthalmology ; : 1-11, 2014.
Article in English | WPRIM | ID: wpr-143119

ABSTRACT

PURPOSE: To investigate the results of graded decompression of orbital fat and walls in Graves' orbitopathy (GO) considering the degree of proptosis reduction at surgery and preoperative computed tomography (CT) findings. METHODS: This is a retrospective interventional case series. Graded orbital fat and wall decompression was performed in 90 orbits of 55 patients. In patients with enlarged extraocular muscles and minimal orbital fat proliferation in preoperative CT scans, one- or two-wall decompression of posterior orbit was performed with minimal fat excision. In other cases, the maximal amount of fat tissue was removed from the post-septal area to the apex. If the proptosis was not satisfactorily symmetrically reduced at surgery, one- or two-wall decompression was performed successively. Symmetric reduction of proptosis was consistently confirmed intraoperatively to assure that a desired amount of exophthalmos reduction was achieved. RESULTS: Four types of decompression were performed: fat only (group 1), fat and one-wall (group 2), fat and two-wall (group 3), and two-wall and minimal fat decompression (group 4). The mean preoperative Hertel value (20.6 +/- 2.8 mm) was reduced significantly at six months postoperatively (16.1 +/- 2.3 mm). Proptosis significantly decreased with a mean of 4.3 +/- 1.7 mm, and the reduction was greatest (5.1 +/- 2.1 mm) in group 3. In group 1, a significant correlation between Hertel change and the volume of resected orbital fat was found (r = 0.479). Diplopia was newly developed or aggravated postoperatively in eight patients, and six of these patients were in group 3. With the exception of one patient, visual acuity improved to nearly normal postoperatively in all patients with optic neuropathy. CONCLUSIONS: Graded orbital decompression of orbital fat and bony walls, as assessed by the degree of proptosis reduction during surgery, was effective and predictable with minimal complications in GO patients with vision-threatening or cosmetically disfiguring proptosis.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Adipose Tissue/surgery , Decompression, Surgical/methods , Follow-Up Studies , Graves Ophthalmopathy/diagnosis , Orbit/surgery , Retrospective Studies , Tomography, X-Ray Computed , Treatment Outcome
14.
Korean Journal of Ophthalmology ; : 1-11, 2014.
Article in English | WPRIM | ID: wpr-143114

ABSTRACT

PURPOSE: To investigate the results of graded decompression of orbital fat and walls in Graves' orbitopathy (GO) considering the degree of proptosis reduction at surgery and preoperative computed tomography (CT) findings. METHODS: This is a retrospective interventional case series. Graded orbital fat and wall decompression was performed in 90 orbits of 55 patients. In patients with enlarged extraocular muscles and minimal orbital fat proliferation in preoperative CT scans, one- or two-wall decompression of posterior orbit was performed with minimal fat excision. In other cases, the maximal amount of fat tissue was removed from the post-septal area to the apex. If the proptosis was not satisfactorily symmetrically reduced at surgery, one- or two-wall decompression was performed successively. Symmetric reduction of proptosis was consistently confirmed intraoperatively to assure that a desired amount of exophthalmos reduction was achieved. RESULTS: Four types of decompression were performed: fat only (group 1), fat and one-wall (group 2), fat and two-wall (group 3), and two-wall and minimal fat decompression (group 4). The mean preoperative Hertel value (20.6 +/- 2.8 mm) was reduced significantly at six months postoperatively (16.1 +/- 2.3 mm). Proptosis significantly decreased with a mean of 4.3 +/- 1.7 mm, and the reduction was greatest (5.1 +/- 2.1 mm) in group 3. In group 1, a significant correlation between Hertel change and the volume of resected orbital fat was found (r = 0.479). Diplopia was newly developed or aggravated postoperatively in eight patients, and six of these patients were in group 3. With the exception of one patient, visual acuity improved to nearly normal postoperatively in all patients with optic neuropathy. CONCLUSIONS: Graded orbital decompression of orbital fat and bony walls, as assessed by the degree of proptosis reduction during surgery, was effective and predictable with minimal complications in GO patients with vision-threatening or cosmetically disfiguring proptosis.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Adipose Tissue/surgery , Decompression, Surgical/methods , Follow-Up Studies , Graves Ophthalmopathy/diagnosis , Orbit/surgery , Retrospective Studies , Tomography, X-Ray Computed , Treatment Outcome
15.
Rev. bras. cir. plást ; 28(3): 398-405, jul.-set. 2013. ilus, tab
Article in English, Portuguese | LILACS | ID: lil-776131

ABSTRACT

Background: Body contouring has recently assumed an important role in body aesthetics. Liposuction in combination with free transplantation of adipose tissue is critical in such procedures. This study assessed the results of fat grafts implanted in unusual sites. Method: Over the past 21 years, the authors have performed 4,405 adipose tissue grafting procedures; 1,407 were classified as transfers to unusual sites. The technique used is based on histological studies and is thoroughly described, including obtaining, preparation, implantation, and postoperative care. The viability of the transplanted tissue was assessed by photographic documentation, a patient questionnaire, and clinical assessment. Results: Part of the transplanted tissue was viable in 100% of cases. The percent volume that remained in the implanted site was approximately 40% of the grafted tissue. The possibility of a late increase in transplanted adipose tissue volume was considered; such changes may be associated with a lack of genetic control in the mesenchymal stem cells present in the adipose tissue. Conclusions: Free transplants of adipose tissue in this series exhibited clinical and percent-wise progress in terms of viability, similar to grafting performed at other sites. Aviability of approximately 40% of grafted adipose tissue was possible because of the care taken throughout the procedure.


Introdução: Recentemente a definição do contorno corporal assumiu importante papel na estética do corpo. A lipoaspiração associada aos transplantes livres de tecido adiposo é fundamental nesses procedimentos. O objetivo deste estudo foi avaliar os resultados dos enxertos gordurosos implantados em locais pouco habituais. Método: Nos últimos 21 anos, os autores realizaram 4.405 enxertos de tecido adiposo, dos quais 1.407 foram classificados como transferidos para locais pouco habituais. A técnica utilizada é fundamentada em estudos histológicos e descrita em todas as suas etapas, isto é, na obtenção, no preparo, na implantação e nos cuidados pós-operatórios. A viabilidade do tecido transplantado foi avaliada através de documentação fotográfica, de questionário respondido pelos pacientes e de avaliação clínica. Resultados: Foi possível comprovar a viabilidade de parte do tecido transplantado em 100% dos casos. O porcentual do volume que permaneceu na local implantado foi de aproximadamente 40% do tecido enxertado. Os autores chamam a atenção para a possibilidade tardia de aumento do volume do tecido adiposo transplantado, e relacionam essa alteração como um provável descontrole gênico das células-tranco mesenquimais presentes no tecido adiposo. Conclusões: Os transplantes livres de tecido adiposo avaliados nesta série apresentaram evolução clínica e porcentual de viabilidade semelhantes aos de enxertos realizados em outros locais. A viabilidade em torno de 40% do tecido adiposo enxertado foi possível graças aos cuidados tomados em todas as etapas do procedimento, conforme a técnica descrita.


Subject(s)
Humans , Male , Female , Child , Adolescent , Young Adult , Middle Aged , Postoperative Care , Surgical Procedures, Operative , Tissue Survival , Transplantation, Autologous , Adipose Tissue/surgery , Histological Techniques/methods , Methods , Patients , Surveys and Questionnaires , Methods
16.
Rev. bras. cir. plást ; 28(1): 49-54, jan.-mar. 2013. ilus, tab
Article in Portuguese | LILACS | ID: lil-687347

ABSTRACT

INTRODUÇÃO: A enxertia de gordura como preenchimento no rejuvenescimento e melhoria do contorno facial vem sendo usada por alguns autores e demonstra um potencial excelente como método de escolha para essa finalidade, uma vez que tem como premissa o princípio básico de corrigir as deformidades com o tecido mais semelhante possível. O objetivo deste trabalho foi avaliar clinicamente a eficiência da enxertia de gordura estruturada na redefinição do contorno facial. MÉTODO: Foi realizada análise retrospectiva de 39 pacientes submetidos a lipoenxertia estruturada para a redefinição do contorno facial, entre 2002 e 2012. A seleção de pacientes incluiu correção de deformidades, assimetrias, harmonização do contorno e aumento da projeção óssea, mas excluiu o rejuvenescimento per se. A avaliação do resultado clínico foi realizada pelo paciente e pelo cirurgião, com auxílio de documentação fotográfica pré e pós-operatória. O resultado clínico foi classificado pelo paciente e cirurgião, empregando escala que variava de 1 a 3: (1) o objetivo não foi alcançado de forma alguma; (2) o objetivo foi alcançado parcialmente; ou (3) o objetivo foi alcançado totalmente. Foi realizado, também, levantamento de prontuários para obtenção dos seguintes dados: idade, alteração ponderal, volume enxertado por área, número de sessões de enxertia realizadas, história de tabagismo e complicações. RESULTADOS: As médias das avaliações do cirurgião e paciente foram, respectivamente, 2,6 ± 0,6 e 2,7 ± 0,5, havendo correlação estatisticamente significante (P < 0,0001). Não foi encontrada relação significativa entre as avaliações e idade, alteração ponderal, volume de enxertia ou tabagismo, com uma única exceção. CONCLUSÕES: A lipoenxertia estruturada demonstrou ser eficiente adjuvante na redefinição do contorno facial e sua eficiência não foi prejudicada por idade, alteração ponderal ou tabagismo. O volume a ser enxertado deve ser adequado às necessidades específicas de cada área.


INTRODUCTION: Fat grafting as a filling method for the rejuvenation and enhancement of facial contours was demonstrated by some authors to be an excellent alternative method for redefining facial contours, based on the premise that the donor tissue used in the correction of the deformities has similar characteristics as the recipient tissue. The objective of the present study was to clinically evaluate the efficiency of structured fat grafting when redefining facial contours. METHODS: A retrospective evaluation was performed in 39 patients who underwent structured fat grafting to redefine their facial contours between 2002 and 2012. The patients selected included those who underwent corrections of deformities, asymmetrical features, contour smoothing, and increased bone projection. Patients who underwent facial contour rejuvenation were excluded. The clinical outcome assessment was performed by the patient and surgeon, with the aid of preoperative and postoperative photographic documentation. The clinical outcome was rated by the patient and surgeon, using a scale ranging from 1 to 3, defined as follows: 1, the objective has not been achieved in any way; 2, the objective was partially achieved; or 3, the objective was fully achieved. In addition, a survey was conducted using the patients' medical charts to obtain the following data: age, weight change, volume grafted by area, number of grafting sessions performed, history of smoking, and complications. RESULTS: The mean surgeon and patient assessment scores were 2.6 ± 0.6 and 2.7 ± 0.5, respectively, with a statistically significant correlation (P < 0.0001). No significant relationship was found between the assessments and age, weight change, graft volume, or smoking habit, with the exception of the cheekbone area. CONCLUSIONS: Structured fat grafting proved to be an efficient adjuvant technique for redefining facial contours, and its efficiency was not affected by age, weight change, or smoking habit. However, the fat volume to be grafted should be adequate for the specific needs of each area.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , History, 21st Century , Rejuvenation , Lipectomy , Adipose Tissue , Medical Records , Retrospective Studies , Plastic Surgery Procedures , Transplants , Face , Facial Asymmetry , Fats , Clinical Study , Injections, Subcutaneous , Rejuvenation/psychology , Lipectomy/methods , Lipectomy/psychology , Adipose Tissue/surgery , Medical Records/standards , Plastic Surgery Procedures/methods , Plastic Surgery Procedures/psychology , Face/abnormalities , Face/surgery , Facial Asymmetry/surgery , Fats/therapeutic use , Injections, Subcutaneous/methods
17.
Rev. bras. cir. plást ; 27(3): 490-492, jul.-set. 2012. ilus
Article in English, Portuguese | LILACS | ID: lil-668157

ABSTRACT

Durante procedimento de lipoaspiração, uma cânula teve seu segmento distal de 3 cm quebrado no plano adiposo. Os autores apresentam, neste trabalho, a conduta adotada para solução do caso, de maneira simples e rápida, com emprego de um intensificador de imagens, sem grandes dificuldades.


During liposuction, 3 cm of the distal segment of the cannula broke within the patient's adipose tissue. We used an image intensifier to easily and quickly address this complication without the development of any sequelae for the patient.


Subject(s)
Humans , Female , Adult , History, 21st Century , Surgery, Plastic , Lipectomy , Adipose Tissue , Adipocytes , Equipment Failure , Cannula , Surgery, Plastic/methods , Lipectomy/adverse effects , Lipectomy/methods , Adipose Tissue/surgery , Adipocytes/physiology , Cannula/adverse effects
18.
Rev. bras. cir. plást ; 26(3): 394-401, July-Sept. 2011. ilus, tab
Article in English, Portuguese | LILACS | ID: lil-608195

ABSTRACT

BACKGROUND: The differences between fetal and adult scars suggest the possibility of manipulating skin scarring outcomes. This study aimed to assess whether the use of adult stem cells from adipose tissue is beneficial to skin healing. METHODS: This was a randomized controlled study for which 18 patients were selected based on inclusion and exclusion criteria. The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. These cells were implanted into the surgical wound dermis in the suprapubic region before skin synthesis. The results were assessed blindly based on the Draaijers scale by three physicians and by the patients themselves in a self-assessment. Photometric assessment by digital photography was also performed. RESULTS: Among the 18 operated patients, considering the surgical result, 17 (94.4 percent) had excellent or good results and one (5.5 percent) had wound dehiscence, which was considered a bad result. Considering skin healing in the searched area, there was no statistically significant difference in the photometric evaluation; in both the self-assessment by the patients and the physicians' assessment, the results were significantly in favor of intervention with stem cells (P = 0.12 and P = 0.003, respectively). Consideration of all assessments (physicians, patients and photometric) found a statistically significant difference in favor of the implantation of adult stem cells from adipose tissue (P <0.001). CONCLUSIONS: Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory.


INTRODUÇÃO: Fatores que diferenciam a cicatrização fetal e a do adulto instigam a possibilidade de manipulação das soluções de continuidade da pele. Este estudo teve como objetivo avaliar se o uso de células-tronco adultas do tecido adiposo é benéfico à cicatrização da pele. MÉTODO: Estudo controlado, randomizado, para o qual foram selecionadas 18 pacientes, considerando-se critérios de inclusão e exclusão. As células-tronco adultas utilizadas eram autólogas, extraídas do tecido adiposo da região infraumbilical, precedendo a realização da abdominoplastia. Essas células, antes da síntese da pele, foram implantadas na derme da ferida operatória, na região suprapúbica. A avaliação dos resultados foi realizada com base na escala de Draaijers, por três avaliadores médicos cegados, e pelas próprias pacientes, por autoavaliação. Foi realizada, também, avaliação fotométrica por fotografia digital. RESULTADOS: Dentre as 18 pacientes operadas, sob o ponto de vista cirúrgico, 17 (94,4 por cento) apresentaram resultados excelentes ou bons e uma (5,5 por cento) apresentou deiscência de sutura, considerado mau resultado. Quanto à cicatrização da pele na área pesquisada, à avaliação fotométrica, não houve diferença estatisticamente significante; à autoavaliação pelas pacientes, os resultados atingiram nível de significância a favor da intervenção com células-tronco (P = 0,12); e à avaliação pelos médicos, foi atingido nível de significância a favor da intervenção por células-tronco (P = 0,003). Considerando-se todas as avaliações realizadas (médicos, pacientes e fotométrica), foi encontrada diferença estatisticamente significante favorável ao implante de células-tronco adultas do tecido adipose (P < 0,001). CONCLUSÕES: Os resultados da cicatrização da pele, após implante de células-tronco adultas derivadas de tecido adiposo, foram satisfatórios.


Subject(s)
Humans , Female , Adult , Middle Aged , History, 21st Century , Photometry , Skin , Wound Healing , Adipose Tissue , Evaluation Study , Abdomen , Adult Stem Cells , Abdominoplasty , Photometry/methods , Skin/injuries , Adipose Tissue/surgery , Adipose Tissue/transplantation , Adult Stem Cells/transplantation , Abdominoplasty/methods , Abdomen/surgery
19.
Salvador; s.n; 2011. 94 p. ilus.
Thesis in Portuguese | LILACS | ID: lil-618640

ABSTRACT

A doença de Chagas, causada pelo protozoário Trypanosoma cruzi, é uma das mais importantes causas de insuficiência cardíaca na América. A terapia celular vem sendo investigada como uma possível opção terapêutica para pacientes com doenças cardiovasculares. Neste estudo foram avaliados os efeitos da terapia com célulastronco mesenquimais em um modelo experimental de cardiomiopatia chagásica crônica. Camundongos C57BL/6 foram infectados com 1000 tripomastigotas da cepa Colombiana de T. cruzi e, após seis meses de infecção, foram tratados com célulastronco mesenquimais derivadas de tecido adiposo humano (CTTAs) ou com meio DMEM (controle). Antes e após 1 e 2 meses de tratamento, os animais chagásicos e controles normais foram submetidos à avaliação cardíaca, incluindo eletrocardiograma, ecocardiograma e teste ergoespirométrico. O grupo tratado recebeu duas injeções intraperitoneais de CTTAs (1x106 células / dose), com um mês de intervalo entre as duas doses. Todos os animais foram sacrificados sob anestesia após 2 meses de tratamento, para análise histopatológica do coração. Não foi observada melhora de arritmias e da função cardiovascular no grupo tratado com CTTAs, porém secções de corações de camundongos deste grupo apresentaram uma redução significativa do número de células inflamatórias (p< 0,0001 ) e da área de fibrose (p< 0,01) em comparação com animais chagásicos tratados com DMEM. A dosagem de 22 citocinas séricas dois meses após o tratamento mostrou um aumento da maioria destas citocinas em animais chagásicos crônicos quando comparados aos controles não-infectados, sendo algumas destas moduladas após a terapia celular. Deste modo, conclui-se que as CTTAs foram capazes de reduzir inflamação e fibrose no coração de camundongos cronicamente infectados por T. cruzi, porém não teve efeitos na função cardíaca dois meses após o transplante.


Subject(s)
Animals , Mice , Chagas Cardiomyopathy/pathology , Heart Diseases/pathology , Stem Cells/immunology , Mesenchymal Stem Cells , Adipose Tissue/surgery , Cell- and Tissue-Based Therapy/methods
20.
Rev. Col. Bras. Cir ; 37(3): 175-183, maio-jun. 2010. ilus, tab
Article in Portuguese | LILACS | ID: lil-554590

ABSTRACT

OBJETIVO: Descrever uma técnica de fechamento de laparostomia através de descolamento cutâneo-adiposo e os resultados obtidos. MÉTODOS: Entre janeiro de 2003 a outubro de 2008 quarenta pacientes laparostomizados com silo plástico (bolsa de Bogotá) foram fechados usando-se a técnica descrita neste trabalho. Dados foram coletados dos prontuários e da busca ativa após alta hospitalar. RESULTADOS: A maioria dos pacientes eram homens (95 por cento), com trauma por arma de fogo (70 por cento). As médias de ISS e APACHE II foram de 28,78 e 20, respectivamente. Hérnia ventral ocorreu em 81,5 por cento dos pacientes, num intervalo médio de seguimento de 9,2 meses. Aproximadamente 1/3 dos pacientes apresentavam hérnias pequenas e não desejavam corrigi-las quando questionados. Somente dois pacientes estavam insatisfeitos com o procedimento em relação a atividades cotidianas e aspectos estéticos. Não houve óbitos ou fístulas intestinais em decorrência do fechamento. CONCLUSÃO: Embora não represente uma técnica de fechamento mioaponeurótico, o descolamento cutâneo-adiposo é simples, seguro e de baixo custo. É uma boa opção terapêutica para os pacientes laparostomizados, principalmente quando o fechamento da aponeurose não for possível nos primeiros 7 a 10 dias.


OBJECTIVE: To describe a technique of laparostomy closure through cutaneous-adipose tissues detachment and its results. METHODS: From January 2003 to october 2008 forty patients in laparostomy (Bogota bag) were engaged in surgical procedures for closing their open abdomens according to the technique described here. Data were collected from patient records and during active search. RESULTS: The majority of patients was men (95 percent) with gunshot wounds (70 percent). The average ISS and APACHE II scores were 28.78 and 20, respectively. Ventral hernias were found in 81.5 percent of patients with a mean follow-up time of 9.2 months. Approximately 1/3 of patients had small hernias and didn't want to have their hernias closed because they didn't feel any functional or anatomic impediment to support the closure at that time. Only two patients were dissatisfied in relation to daily activities and to the surgical procedure itself. There were neither deaths nor intestinal fistula with this type of closure. CONCLUSION: Although it doesn't represent a technique for fascial closure, it is simple to perform, safe, and with low cost. It is a therapeutic option for patients with open abdomen, especially if closure of the aponeurosis was not possible in the first 7 to 10 days.


Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Young Adult , Abdomen/surgery , Laparotomy/methods , Adipose Tissue/surgery , Skin/surgery , Young Adult
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